The geopolitical dynamics of Southeast Asia in the post-pandemic era are experiencing significant changes due to global and regional challenges. One of the main changes is a shift in economic power. Countries such as Vietnam and Indonesia are now increasingly receiving world attention. Vietnam, for example, has succeeded in attracting foreign investment through pro-business policies and political stability, making it an attractive alternative for companies looking to diversify supply risks. Indonesia, with the largest population in Southeast Asia, has the potential to become a new economic center. Actively establishing cooperation in the fields of trade, investment and infrastructure through various initiatives such as RCEP (Regional Comprehensive Economic Partnership). Membership in RCEP also strengthens the position of Indonesia and other ASEAN countries in regional trade. The global health crisis has also shown how important multisectoral cooperation is. Together, ASEAN countries are forming a collective response to COVID-19. The ASEAN COVID-19 Response Fund initiative and cooperation in procuring vaccines are clear examples of solidarity in facing the crisis. However, the involvement of large countries, such as China and the United States in the region, presents new challenges. China’s strategy, through the Belt and Road Initiative, offers infrastructure investment, but also raises concerns about economic interdependence. On the other hand, the US is trying to strengthen alliances with ASEAN countries by offering security and investment alternatives, showing that global power competition is increasingly sharpening. The South China Sea issue remains a major source of tension. Some countries, such as the Philippines and Malaysia, have overlapping claims to the region. Meanwhile, the involvement of large countries complicates dialogue and negotiations. ASEAN’s mediation efforts in resolving this dispute show the important role of regional organizations in creating stability. The digital transformation accelerated by the pandemic also has an impact on Southeast Asia’s geopolitics. Countries are starting to adopt digital technology to improve government and economic efficiency. It can be seen from the increase in e-commerce platforms in Indonesia, Malaysia and Thailand which have become new engines of economic growth. This creates opportunities, but also challenges in terms of regulation and data privacy. Apart from that, climate change is a critical issue. Countries in Southeast Asia are one of the most vulnerable to the impacts of climate change, such as natural disasters and rising sea levels. Regional cooperation in climate mitigation and adaptation is inevitable, with various initiatives such as the ASEAN Agreement on Disaster Management and Emergency Response. Not to mention, social issues such as economic inequality and human rights have come to the surface. The widening gap between urban and rural areas in many countries could add to instability. Responses to these issues are important in maintaining social harmony and avoiding potential conflict. The geopolitical dynamics of Southeast Asia in the post-pandemic era is a complex picture involving the interaction of many factors, ranging from global forces, regional cooperation, to social and environmental challenges. Understanding this aspect is key for countries to navigate forward in maintaining stability and prosperity in the region.